Most people fear the end. They usually lose friends and family. More to the point, most people fear DEATH. Some people die at a young age and never get to make something of themselves, they would do anything, ANYTHING, to escape it. Then there’s the small percent of people who actually want it to end. Some because they lost everything that made life worth living, others because they feel so much pain, physical or emotional, that they would want to end it as soon as possible.
As for me, I would only end it if everything and everyone that I cared about slipped away from my grasp forever. Although I hope that it will never have to come to that. For I doubt that I would ever have the strength to do such a thing.